Urethane produces long lasting anesthesia with rapid onset following IP administration. It has minimal effects on the cardiovascular and respiratory systems. Urethane provides good analgesia as well as excellent muscle relaxation.

Disadvantages to using urethane:

  • At high doses, hypotension, hypothermia, bradycardia, and metabolic acidosis are seen.
  • It is absorbed through the skin and, following topical administration to rodents, can produce sedation and ataxia.
  • It is a proven carcinogen and mutagen in rodents.

If urethane is selected as an anesthetic, personnel must take precautions to adequately protect themselves while mixing a urethane solution. Proper protection should include a double set of gloves, face mask, and mixing under chemical fume hood. Urethane is not recommended for survival procedures.

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